Hangzhou Nyowani-Test Inotangisa Epoch-kugadzira Pet Diagnostic Chigadzirwa Chitsva - Canine uye Feline Renal Basa 3-in-1 combo Test Kit
Hangzhou Nyowani-Test Biotechnology Co., Ltd yakazivisa zviri pamutemo kuvhurwa kwezviviri epoch-kugadzira zvigadzirwa zvitsva zvekuongororwa kwemhuka kumusika wepasirese pet immuno-diagnostic musika: iyo Canine/Feline renal basa Triple Test Kit (Creatinine/SDMA/CysC Triple Test) (Fig. 1 uye Fig. 2), iyo inounza mhinduro itsva uye yakarurama yekuongorora hutano hwemhuka uye kurapwa.
Mufananidzo 1 Canine renal function triple test kit Mufananidzo 2 Feline renal function triple test kit
Muna Gumiguru 2022, New-Test Biotechnology Co., Ltd. ndiyo yaive yekutanga kuvhura pasi rose multi-channel multiplex fluorescence immunoassay analyzer, NTIMM4 (chizvarwa chechitatu, ona Mufananidzo 3), uye muna 2024, itsva single-channel multiplex immunofluorescence. analyzer, NTIMM2 (chizvarwa chechina, ona Mufananidzo 4). Iyo yazvino canine/feline renal function 3-in-1 combo test kit inoenderana nemhando mbiri.
Mufananidzo 3 NTIMM4 Mufananidzo 4 NTIMM2
Nyanzvi mudiki mamorekuru assay tsvakiridzo nekusimudzira kwemakore matanhatu, zvigadzirwa zvitsva zvinotangwa.
Kurongeka kwekuonekwa kwemamorekuru madiki kwagara kuri kunetsa kukunda mumunda wePOCT kuyedzwa, uye zvakare igwara rekutsvaga nekusimudzira iro Nest-Test Bio yakapihwa kubva payakavambwa anopfuura makore matanhatu apfuura. Iko kudzima kwemuviri uye kuora kwemaitiro echinyakare fluorescent zvinhu zvinokanganisa zvakananga kurongeka kwediki molecule yekuona mhinduro. Rare-earth nanocrystal labeling tekinoroji, chizvarwa chechina chefluorescent nanomaterials yakagadziriswa neNew-Test, inozivikanwa seyakagadzika fluorescent nanomaterials pamusika, ine mukana wekukunda hunhu hwekudzima mwenje. Yakabatana nemakore akati wandei ekuenderera mberi kwekugadzirisa maitiro, yakazogadzirisa dambudziko repasi rose rekusarongeka muPOCT diki molecule yekuyedza. Yekutanga kusunda iitsvo inoshanda katatu test kit. Inovimbisa huchokwadi uye kugadzikana kwemamorekuru maviri madiki (creatinine & SDMA) yekuona reagents mukati memakore maviri echokwadi nguva.
“Iyo imwechete bvunzo iripo zvakare, saka sei uchigadzira renal function triad”—Magadzirirwo erenal function triad
Parizvino, zviratidzo zvinowanzoonekwa zvekushanda kwetsvo dzisina kujairika mumbwa nemakati zvinosanganisira creatinine (CREA) uye urea nitrogen mu biochemistry; CysC (cystatin C) uye symmetric dimethylarginine (SDMA) mukudzivirira zviratidzo, nezvimwewo. Parizvino, zvinotendwa kuti zvose zvataurwa pamusoro apa - zviratidzo zvinosefa kuburikidza neglomerulus. Kana iyo glomerular filtration rate yadzikira nekuda kwekukuvara kweitsvo, zviratidzo izvi zvinoungana muropa uye kuwedzera mukusimbisa, zvichiratidza dhigirii renal - kusashanda zvakanaka. The International Society for Research in Kidney Diseases (IRIS) grading system inoronga kusakanganiswa kwetsvo mumakitsi kuita magiredhi mana zvichienderana nekukosha kwecreatinine (Giredhi I, yakajairika kana nyoro: <1.6 mg/dL; Giredhi II, ine mwero: 1.6-2.8 mg / dL; Giredhi III, yakaoma: 2.8-5.0 mg/dL; mg/dL).
Kukanganiswa kwerenal muimbwa kunorongwa mumagiredhi mana (Giredhi I, yakajairika kana nyoro: <1.4 mg/dL: Giredhi II, ine mwero: 1.4-2.0 mg/dL: Giredhi III, yakaoma: 2.0-4.0 mg/dL: Giredhi IV, uye danho rekupedzisira:> 4.0 mg/dL). Zvisinei, nekuda kwekunzwa kushoma kwe creatinine mukutanga kwechirwere chetsvo chisingaperi (CKD), chimwe chiratidzo chekare chenephron function filtration, "symmetric dimethylarginine (SDMA)", yakashandiswa. Zvinoenderana nedata, SDMA inogona kuratidza kusagadzikana pa25-40% yerenal impairment, nepo creatinine inowanzoonekwa seyakajairika pa75% yehurema.
CysC (cystatin C) inonzi cysteine protease inhibitor, yakaderera molecular weight (13.3 kD), isiri-glycosylated basic protein. Ndiyo imwe yeanonyanya kushandiswa mamakisi ekutanga renal basa mukurapa kwevanhu. Kufanana necreatinine uye SDMA, inosefa kuburikidza neglomerulus, asi inosiyana necreatinine uye SDMA pakuti metabolism yayo haisi kuburikidza neurinary tract, asi inenge yakanyatsogadziriswa nekugadzirisa zvakare kuburikidza nerenal tubules. zvisati zvamboonekwa, zvichitungamirira nyanzvi dzakawanda, nyanzvi uye mabhuku kune mhedziso mbiri dzakasiyana pamusoro pekukuvara kweitsvo kusingaperi mumakati: vamwe vanotenda kuti CysC ndiyo. chiratidzo chekutanga chekukuvara kweitsvo chisingaperi chinogona kushandiswa mumbwa nekatsi, nepo vamwe vachitenda kuti CysC inoenderana zvine mwero mu canine CKD, asi zvisina kunaka mumakati.
Sei paine mhedziso mbiri dzakapesana kubva kune imwecheteyo "glomerular filtration function index"?
Chikonzero chacho ndeche Anuria, inova mamiriro ezvinhu akawandisa mumakati kupfuura mune mamwe marudzi, kunyanya mumakati echirume. Mamwe data anoratidza kuti chiitiko cheAnuria mumakati echirume chakakwira se68.6%, uye Anuria ichaguma yakananga mukuvharwa kwekubuda kwe creatinine, ropa urea nitrogen uye SDMA. Iyo mhuka inogara ichigadzirisa uye ichigadzira itsva creatinine, ropa urea nitrogen uye SDMA, pakuona zviratidzo zvose zvitatu muropa panguva ino, pachava nekuwedzera kwakanyanya kana kunyange kuputika kwezviratidzo pasinei nokuti glomerulus yakanyatsokuvadzwa.
CysC ine kukosha kwayo kwakasiyana panguva ino, kunyangwe ichi chiratidzo chiri glomerular filtration, haina metabolized neweti, iri kuburikidza netubular yekudzoreredza. Kana Anuria ikaitika asi renal basa rakajairwa, iyo CysC index inogona kuramba ichichengetwa pamwero wakajairwa. Chete kana glomerulus kana kukuvara kwetubular kuchiitika, iyo CysC index inosimudzwa kuita isina kujairika. Naizvozvo, kucherechedzwa kweese matatu indexes kunogona kuita kuongororwa kwakaringana uye kupa kurapa kunoenderana nekukurumidza uye nemazvo.
New-Test renal function marker 3-in-1 test kits inopa kukosha kutsva kwekiriniki pakuona kwekukuvara kwerenal mumbwa nekatsi!
Kutsanangura misimboti uye kusanganisa nehunhu hwezviratidzo, iyo New-Test renal function marker 3-in-1 test kits yakazvarwa ine yakakosha kuchipatara kukosha kwembwa nekatsi (kunyanya katsi) neAnuria:
New-Test renal function marker 3-in-1 test kits inoshandiswa kusiyanisa kana paine chaiyo renal basa kukuvara muAnuria mamiriro kana kukonzera blockage kukwidziridzwa indexes nekuda kweAnuria. Chaiyo renal basa kukuvara kunoda chete weti catheterization uye yakabatana nehanya, uye kufungidzira kunowanzo kuve nani. Kukwidziridzwa kwemaindex hakungodi chete weti catheterization uye anti-kuzvimba kurapwa, asiwo kurapa kwakabatana nechirwere chetsvo, uye fungidziro yacho inonetsa, uye inogona kushanduka kuita chirwere cheitsvo chisingaperi.
Pazasi pane New-Test renal function marker 3-in-1 test kits data yeyakajairika Anuria (Isiri-chaiyo itsvo kukuvara) uye Anuria + kukuvara kweitsvo muNew-Test kiriniki yekutsvagisa nyaya:
| Anuria kuonekwa Nyowani-Test renal function marker 3-in-1 test kits | Project | Mhedzisiro | Mhedzisiro |
| Creatinine | + | + | |
| SDMA | + | + | |
| CysC | + | - | |
| Mhedziso | Anuria yakakonzera kukuvara kwerenal | Yekutanga nhanho yeAnuria uye renal kukuvara kana Anuria iyo isati yasvika renal kukuvara |
Pazasi pane chikamu cheyakajairika data yekiriniki uye tsananguro yekesi yeNew-Test renal basa 3-mu-1 test kits:
| Katsi | Medical History | Clinical Symptom | CysC(mg/L) | SDHA (ug/dL) | CR(mg/dL) | Mhedziso |
| 2024090902 | Cystitis/ Kukuvara kwerenal | Mamiriro ezvinhu akaipa epfungwa, Kushaya chido chekudya, Abnormal renal index, Anuria (Chisingaperi renal kutadza, anuria) | 1.09 | 86.47 | 8.18 | Renal kukuvara neAnuria |
| 2024091201 | / | Kuipa kwepfungwa mamiriro, Anuria, Abnormal renal basa | 0.51 | 27.44 | 8.21 | Hapana kukuvara kwerenal neAnuria/Early stage |
| 2024092702 | / | Anuria | 0.31 | >100.00 | 9.04 | Hapana kukuvara kwerenal neAnuria/Early stage |
| 2024103101 | / | Anuria | 0.3 | 14.11 | 6.52 | Hapana kukuvara kwerenal neAnuria/Early stage |
| 2024112712 | Anuria | 0.5 | >100.00 | 8.85 | Hapana kukuvara kwerenal neAnuria/Early stage | |
| 2024112601 | Dysuria/Anuria | 0.43 | >100.00 | 9.06 | Hapana kukuvara kwerenal neAnuria/Early stage | |
| 0.47 | >100.00 | 878 | Hapana kukuvara kwerenal neAnuria/Early stage | |||
| 2024112712 | / | Anuria | 0.54 | 94.03 | 8.64 | Hapana kukuvara kwerenal neAnuria/Early stage |
Mumamiriro ezvinhu eAnuria, nekuda kwekusiyana kwemukati wemetabolism metabolism yeindekisi imwe neimwe, pachava nemhedzisiro misiyano mikuru kune imwechete renal function filtration index. Nokudaro, kurongeka kwakajairika kwekukuvadzwa kwerenal creatinine kana SDMA haichashandisi, uye mhedziso yekiriniki yepedyo inogona kuwanikwa chete nekubatanidza kuongorora nechimwe chiratidzo "CysC". Zvinokurudzirwa kuti marabhoritari (zvipatara) zvimise zviyero zvemukati zvinoenderana neruzivo rwekiriniki, kuitira kuti vaongorore zvakanyanya uye zvitsva kukosha kwekiriniki.
Chekupedzisira, New-Test Biotech inotarisira kuti chinyorwa ichi chichakanda kunze chidhinha kukwezva jade, uye inotarisira kuti vazhinji veChinese veterinary drug uye diagnostic reagent vagadziri vachagadzira zvigadzirwa zvakakosha zvekiriniki uye nekubatsira vamwe veterinarian vekumba kuti vasvike padanho repamusoro nyika!
Appendix: Kugamuchirwa kwePatent Chikumbiro cheIntellectual Property Dziviriro
Nguva yekutumira: Jan-22-2025
